CCL17 in Inflammation and Pain

CCL17 blockade as a therapy for osteoarthritis pain and disease

BACKGROUND Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→interferon regulatory factor 4 (IRF4)→chemokine (c-c motif) ligand 17 (CCL17) pathway, which is important for the development of inflammatory arthritis pain and disease. Tumour ne...

comparative study of pain relieving effect of dry cotton pellet and eugenol cotton pellet in the reduction of pain in emergoney pulpotomy

چکیده ندارد.

Inflammation and pain

Inflammatory pain is characterized by an increased response to mechanical or heat stimuli, which are normally only mildly painful (mechanical or thermal hyperalgesia). Inflammatory mediators may elicit pain by activating peripheral nociceptors, by promoting further release of inflammatory mediators and, most significantly, by sensitizing primary afferent neurons to any kind of stimuli. On the o...

Trpa1 Channels in Visceral Inflammation and Pain

Compartmentalized Production of CCL17 In Vivo

Dendritic cells (DCs)(*) fulfill an important regulatory function at the interface of the innate and adaptive immune system. The thymus and activation-regulated chemokine (TARC/CCL17) is produced by DCs and facilitates the attraction of activated T cells. Using a fluorescence-based in vivo reporter system, we show that CCL17 expression in mice is found in activated Langerhans cells and mature D...